Birmingham, Sandwell, Solihull and environs APC Formulary
Maintained by Midlands and Lancashire Commissioning Support Unit
 
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8 Malignant disease and immunosuppression

For the most up to date list of agents funded by the Cancer Drugs Fund, please see Cancer Drug Fund list

08-01-05 Other antineoplastic drugs

Abemaciclib Verzenios®
Formulary

In line with NICE

Link  Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy [TA579]
Link  NICE TA 563: Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
 

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Bosutinib Bosulif®
Formulary
  • In line with NICE
  • Hospital only- NHSE commissioned
  • Link  TA401: Bosutinib for previously treated chronic myeloid leukaemia
     

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    Brigatinib Alunbrig®
    Formulary

    In line with NICE

    Link  NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
     

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    Carfilzomib Kyprolis®
    Restricted
    In line with NICE
    Link  NICE TA457: Carfilzomib for previously treated multiple myeloma
     

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    Cemiplimab
    Formulary

    Use in line with NICE

    Link  NICE TA592: Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
     

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    Ceritinib  Zykadia®
    Formulary

    In line with NICE

    Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
     

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    Dabrafenib with Trametinib
    Formulary

    In line with NICE

    Link  NICE TA 544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
     

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    Daratumumab Darzalex®
    Formulary

    In line with NICE

    Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
    Link  NICE TA573: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
     

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    Dupilumab
    Formulary

    In line with NICE

    Link  NICE TA 534: Dupilumab for treating moderate to severe atopic dermatitis
     

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    Durvalumab
    Formulary

    In line with NICE

    Link  Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation [TA578]
     

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    Encorafenib with binimetinib
    Formulary

    In line with NICE

    Link  NICE TA 562: Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma
     

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    Eribulin Halaven®
    Formulary
  • In line with NICE
  • Hospital only- NHSE commissioned
  • Link  TA423:Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
     

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    Ibrutinib Imbruvica®
    Formulary
    • In line with NICE
    • Hospital only- NHSE commissioned
    Link  NICE TA 502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
    Link  NICE TA 491: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
     

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    Idelalisib Zydelig®
    Formulary
  • NHS England is responsible commissioner for its use in chronic lymphocytic leukaemia(as per NICE TA 359)
  • Link  NICE TA 359: Idelalisib for treating chronic lymphocytic leukaemia (Oct 2015)
     

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    Ixazomib
    Restricted

    In line with NICE

    Hospital only - NHSE commissioned.

    Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
     

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    Lenvatinib Kisplyx®
    Formulary

    In line with NICE

    Link  NICE TA 498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
    Link  NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
    Link  NICE TA551: Lenvatinib for untreated advanced hepatocellular carcinoma
     

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    Midostaurin  Rydapt®
    Formulary

    In line with NICE

    NHSE commissioned

    Link  NICE TA523:Midostaurin for untreated acute myeloid leukaemia
     

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    Nintedanib Vargatef®
    Formulary
    • Hospital only- NHSE commissioned
    • In line with NICE and available from day 91 following publication of TA.
    Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
     

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    Niraparib
    Formulary
    Link  NICE TA 528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
     

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    Niraparib
    Formulary

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    Olaparib Lynparza®
    Formulary
    • Hospital only- NHSE commissioned
    • In line with NICE and available from day 91 following publication of TA.
    Link  NICE TA381: Olaparib for the maintenance treatment of ovarian, fallopian tube and peritoneal cancer
    Link  NICE TA598: Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
     

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    Palbociclib Ibrance®
    Formulary
  • In line with NICE
  • Hospital only - NHSE commissioned
  • Link  NICE TA 495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
     

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    Panobinostat Farydak®Restricted Item
    Formulary
  • Hospital only- NHSE commissioned
  • In line with NICE and available from day 91 following publication of TA.
  • Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
     

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    Pegaspargase Oncaspar®
    Restricted
  • Hospital only- NHSE Commissioned
  • In line with NICE and available from day 91 following publication of TA.
  • Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia-
     

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    Pembrolizumab Keytruda®
    Formulary
  • NHS England is responsible commissioner in line with NICE (see links below)
  • Link  NICE TA 557: Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
    Link  NICE TA522: Pembrolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
    Link  NICE TA519: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
    Link  NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
    Link  NICE TA 366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab (Nov 2015)
    Link  NICE TA 540: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
    Link  NICE TA 600: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
    Link  NICE TA553: Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
    Link  NICE TA 357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab (Oct 2015)
     

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    Ribociclib Kisqali®
    Formulary
  • In line with NICE
  • Hospital only - NHSE commissioned
  • Link  NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
    Link  NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
     

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    Ruloxitinib Jakavi®
    Formulary
  • Hospital only- NHS England is responsible commissioner
  • In line with NICE and available from day 91 following publication of TA (see links below)
  • Link  NICE TA 386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
     

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    Talimogene laherparepvec Restricted Item  Imlygic®
    Formulary
  • Hospital only- NHS E commissioned
  • In line with NICE and available from day 91 following publication of TA (see link below)
  • Link  NICE TA410: Unresectable metastatic melanoma- Talimogene laherparepvec
     

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    Tisagenlecleucel Kymriah®
    Formulary

    In line with NICE

    Link  NICE TA554: Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 years
    Link  NICE TA567: Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies
     

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    Osimertinib
    Formulary
    In line with NICE
    Link  TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
     

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    Venetoclax Venclyxto®
    Formulary
  • In line with NICE
  • Link  NICE TA 487: Venetoclax for treating chronic lymphocytic leukaemia
    Link  NICE TA 561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
     

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    Axitinib Inlyta®
    Non Formulary

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