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Birmingham, Sandwell, Solihull and environs APC Formulary
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:

For the most up to date list of agents funded by the Cancer Drugs Fund, please see Cancer Drug Fund list

 Details...
08.01  Cytotoxic drugs
08.01  Side-effects of cytotoxic drugs
08.01  Drugs for cytotoxic-induced side-effects
Calcium Folinate
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Formulary
Red
 
   
Dexrazoxane (Savene®)
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Formulary
Red
 
   
Mesna
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Formulary
Red
 
   
08.01.01  Alkylating drugs
Cytotoxic Drug Bendamustine
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Formulary
Red
Cancer Drugs Fund
 
Link  NICE TA216: Bendamustine for CLL
   
Cytotoxic Drug Busulfan (Tablets)
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Formulary
Red
 
   
Cytotoxic Drug Carmustine (Gliadel®)
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Formulary
Red
 
Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
   
Cytotoxic Drug Chlorambucil (Tablets)
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Formulary
Red
 
   
Cytotoxic Drug Cyclophosphamide (Tablets)
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Formulary
Red
  • For oncology 
  •    
    Cytotoxic Drug Estramustine Phosphate (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Cytotoxic Drug Lomustine (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Cytotoxic Drug Melphalan (Tablets)
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    Formulary
    Red
     
       
    Cytotoxic Drug Treosulfan (Capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.02  Anthracyclines and other cytotoxic antibiotics to top
    Cytotoxic Drug Doxorubicin Hydrochloride (Lipid formulation)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA 389: Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
       
    Cytotoxic Drug Idarubicin Hydrochloride (Capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.03  Antimetabolites
    Cytotoxic Drug Azacitidine (Vidaza®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA218: azacitidine for myelodysplastic syndromes
       
    Cytotoxic Drug Capecitabine (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
    Link  NICE TA191: Gastric cancer (advanced) - capecitabine
    Link  NICE TA61: Colorectal cancer - capecitabine and tegafur uracil
       
    Cytarabine–daunorubicin liposomal (Vyxeos®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA552: Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemia
       
    Cytotoxic Drug Fludarabine Phosphate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
    Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
       
    Cytotoxic Drug Gemcitabine (Gemzar®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE NG85: Pancreatic cancer in adults: diagnosis and management
    Link  NICE TA116: Breast cancer - gemcitabine
       
    Cytotoxic Drug Mercaptopurine (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Red for cancer indications

    See section 01.05.03 for use in IBD

     
       
    Cytotoxic Drug Methotrexate 2.5mg (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Red for cancer indications 

    See section 13.05.03 for psoriasis, 01.05.03 for Crohn's disease, 03.12 for interstitial lung disease and 10.01.03 for rheumatology indications.

     
    Link  UKMI Q&A: Should patients drink alcohol whilst taking long-term low-dose methotrexate?
    Link  UKMI Q&A: What is the clinical significance of the interaction between methotrexate and penicillins? (Oct13)
       
    Cytotoxic Drug Pemetrexed (Alimta®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA124: Lung cancer (non-small-cell) - pemetrexed - prior chemotherapy
    Link  NICE TA135: Mesothelioma - pemetrexed disodium
    Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
    Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
    Link  NICE TA402: Lung cancer (non-squamous non-small-cell) after pemetrexed and cisplatin: Pemetrexed (maintenance)
       
    Raltitrexed (Tomudex®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE CG131:Colorectal cancer: diagnosis and management
       
    Cytotoxic Drug Tioguanine (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Cytotoxic Drug Trifluridine-tipiracil  (Lonsurf ®)
    (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only- NHSE commissioned 
  • Link  NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
       
    08.01.04  Vinca alkaloids and etoposide
    Cytotoxic Drug Vinorelbine
    (capsules)
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    Formulary
    Red
     
       
    08.01.05  Other antineoplastic drugs
    Abemaciclib (Verzenios®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    In line with NICE

     
    Link  Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy [TA579]
    Link  NICE TA 563: Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
       
    Bosutinib (Bosulif®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only- NHSE commissioned 
  • Link  TA401: Bosutinib for previously treated chronic myeloid leukaemia
       
    Brigatinib (Alunbrig®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
       
    Carfilzomib (Kyprolis®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA457: Carfilzomib for previously treated multiple myeloma
       
    Cemiplimab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    NHS England

    Use in line with NICE

     
    Link  NICE TA592: Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
       
    Ceritinib Black Triangle (Zykadia®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    NHS England

    In line with NICE

     
    Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
       
    Dabrafenib with Trametinib
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    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA 544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
       
    Daratumumab (Darzalex ®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    NHS England

    In line with NICE

     
    Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
    Link  NICE TA573: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
       
    Dupilumab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    CCG
    Homecare

    In line with NICE

     
    Link  NICE TA 534: Dupilumab for treating moderate to severe atopic dermatitis
       
    Durvalumab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    NHS England

    In line with NICE

     
    Link  Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation [TA578]
       
    Encorafenib with binimetinib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    In line with NICE

     
    Link  NICE TA 562: Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma
       
    Cytotoxic Drug Eribulin (Halaven®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only- NHSE commissioned 
  • Link  TA423:Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
       
    Ibrutinib (Imbruvica®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
    NHS England
    • In line with NICE
    • Hospital only- NHSE commissioned
     
    Link  NICE TA 502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
    Link  NICE TA 491: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
       
    Idelalisib (Zydelig®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • NHS England is responsible commissioner for its use in chronic lymphocytic leukaemia(as per NICE TA 359)
     
  • Link  NICE TA 359: Idelalisib for treating chronic lymphocytic leukaemia (Oct 2015)
       
    Ixazomib
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    Cancer Drugs Fund
    NHS England

    In line with NICE

    Hospital only - NHSE commissioned.

     
    Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
       
    LenvatinibBlack Triangle (Kisplyx ®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    NHS England

    In line with NICE

     
    Link  NICE TA 498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
    Link  NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
    Link  NICE TA551: Lenvatinib for untreated advanced hepatocellular carcinoma
       
    Midostaurin  (Rydapt® )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

    NHSE commissioned

     
    Link  NICE TA523:Midostaurin for untreated acute myeloid leukaemia
       
    Nintedanib (Vargatef ®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    • Hospital only- NHSE commissioned
    • In line with NICE and available from day 91 following publication of TA.
     
    Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
       
    Niraparib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England
     
    Link  NICE TA 528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
       
    Niraparib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England
     
       
    Olaparib (Lynparza ® View adult BNF View SPC online View childrens BNF Formulary
    Red
    High Cost Medicine
    • Hospital only- NHSE commissioned
    • In line with NICE and available from day 91 following publication of TA.
     
    Link  NICE TA381: Olaparib for the maintenance treatment of ovarian, fallopian tube and peritoneal cancer
    Link  NICE TA598: Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
       
    Palbociclib (Ibrance®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only - NHSE commissioned 
  • Link  NICE TA 495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
       
    Panobinostat (Farydak®Restricted Item View adult BNF View SPC online View childrens BNF Formulary
    Red
    High Cost Medicine
  • Hospital only- NHSE commissioned
  • In line with NICE and available from day 91 following publication of TA.
     
  • Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
       
    Pegaspargase (Oncaspar®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
  • Hospital only- NHSE Commissioned
  • In line with NICE and available from day 91 following publication of TA.
     
  • Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia-
       
    Pembrolizumab (Keytruda®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
  • NHS England is responsible commissioner in line with NICE (see links below)
     
  • Link  NICE TA 557: Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
    Link  NICE TA522: Pembrolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
    Link  NICE TA519: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
    Link  NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
    Link  NICE TA 366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab (Nov 2015)
    Link  NICE TA 540: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
    Link  NICE TA 600: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
    Link  NICE TA553: Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
    Link  NICE TA 357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab (Oct 2015)
       
    Ribociclib (Kisqali®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only - NHSE commissioned 
  • Link  NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
    Link  NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
       
    Ruloxitinib (Jakavi® View adult BNF View SPC online View childrens BNF Formulary
    Red
  • Hospital only- NHS England is responsible commissioner
  • In line with NICE and available from day 91 following publication of TA (see links below)
     
  • Link  NICE TA 386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
       
    Talimogene laherparepvec Restricted Item  (Imlygic®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • Hospital only- NHS E commissioned
  • In line with NICE and available from day 91 following publication of TA (see link below)
     
  • Link  NICE TA410: Unresectable metastatic melanoma- Talimogene laherparepvec
       
    Tisagenlecleucel (Kymriah®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    NHS England

    In line with NICE

     
    Link  NICE TA554: Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 years
    Link  NICE TA567: Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies
       
    Osimertinib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
    In line with NICE 
    Link  TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
       
    Venetoclax (Venclyxto® )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
  • In line with NICE 
  • Link  NICE TA 487: Venetoclax for treating chronic lymphocytic leukaemia
    Link  NICE TA 561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
       
    08.01.05  Amsacrine
    08.01.05  Arsenic trioxide to top
    Cytotoxic Drug Arsenic Trioxide (Trisenox®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England
    • In line with NICE
     
    Link  NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
       
    08.01.05  Bevacizumab
    Bevacizumab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
  • Funding available through Cancer Drugs Fund (CDF) for indications listed in CDF list.
  • Click here to access latest CDF list.  
  • Link  NICE TA212: Colorectal cancer (metastatic) - bevacizumab
    Link  NICE TA214: Breast Cancer with taxane
    Link  NICE TA242: Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab (review)
    Link  NICE TA263: Breast cancer with capecitabine
    Link  NICE TA284: Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer
    Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
       
    08.01.05  Bexarotene
    Bexarotene
    (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.05  Bortezomib
    Bortezomib (Velcade®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
  • In line with NICE 
  • Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
    Link  NICE TA311: Multiple myeloma - bortezomib (induction therapy
    Link  NICE TA228: Bortezomib and thalidomide for the first-line treatment of multiple myeloma
    Link  NICE TA129: Multiple myeloma - bortezomib
       
    08.01.05  Brentuximab vedotin
    Brentuximab vedotin (Adcetris®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    • In line with NICE
     
    Link  NICE TA478: Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
    Link  NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
    Link  NICE TA577: Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
       
    08.01.05  Cetuximab to top
    Cetuximab (Erbitux®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA118: Colorectal cancer (metastatic) - bevacizumab & cetuximab
    Link  NICE TA145: Head and neck cancer - cetuximab
    Link  NICE TA242: Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab (review)
    Link  NICE TA439:Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
    Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
       
    08.01.05  Crisantaspase
    Crisantaspase (Erwinase®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.05  Dacarbazine and Temozolomide
    Cytotoxic Drug Dacarbazine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Cytotoxic Drug Temozolomide (Temodal®)
    (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
    Link  NICE TA23: Brain cancer - temozolomide
       
    08.01.05  Erlotinib
    Erlotinib (Tarceva® )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • in line with NICE and available from day 91 following publication of TA. 
  • Link  NICE TA374: Lung cancer (non-small cell, locally advanced or metastatic)- erlotinib and gefitinib after prior chemotherapy
    Link  NICE TA258: Lung cancer (non small cell, EGFR-TK mutation positive) - erlotinib (1st line)
    Link  NICE TA227: Lung cancer (non-small-cell, advanced or metastatic maintenance treatment) - erlotinib (monotherapy)
       
    08.01.05  Hydroxycarbamide
    Cytotoxic Drug Hydroxycarbamide
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • For myeloproliferative disorders.
  • Supported by an ESCA (in development)

  • For use in sickle cell- see chapter 9
     
  •    
    08.01.05  Ipilimumab to top
    Ipilimumab (Yervoy®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
    Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
       
    08.01.05  Mitotane
    Mitotane (Lysodren®)
    (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.05  Panitumumab
    Panitumumab (Vectibix®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA242: Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab (review)
    Link  NICE TA439: Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
       
    08.01.05  Pentostatin
    08.01.05  Platinum compounds
    Cytotoxic Drug Oxaliplatin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
       
    08.01.05  Porfimer sodium and temoporfin to top
    08.01.05  Procarbazine
    Cytotoxic Drug Procarbazine
    (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.01.05  Protein kinase inhibitors
    Afatinib (Giotrif®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE 
  • Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
       
    Alectinib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  Alectinib for untreated ALK-positive advanced non-small-cell lung cancer
       
    Cabozantinib (Cabometyx®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA463: Cabozantinib for previously treated advanced renal cell carcinoma
    Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
       
    Crizotinib (Xalkori®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
  • Hospital only- NHSE commissioned
  • In line with NICE 
  • Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
    Link  NICE TA406:Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
    Link  NICE TA 529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
       
    Dacomitinib
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    Use in line with NICE

     
    Link  NICE TA595: Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
       
    Dasatinib (Sprycel®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
    In line with NICE 
    Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
    Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
       
    Everolimus (Afinitor®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE
    Hospital only-NHSE commissioned 
    Link  NICE TA449: Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
    Link  NICE TA432: Everolimus for advanced renal cell carcinoma after previous treatment
    Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
       
    Everolimus (Votubia®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Gefitinib (Iressa®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
       
    Cytotoxic Drug Imatinib (Glivec®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    in line with NICE 
    Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
    Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
    Link  NICE TA326: Gastrointestinal stromal tumours - imatinib (adjuvant): guidance
    Link  NICE TA209: Gastrointestinal stromal tumours (unresectable/metastatic) - imatinib. NOT RECOMMENDED
    Link  NICE TA86: Gastro-intestinal stromal tumours (GIST) - imatinib
       
    Lapatinib (Tyverb®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
       
    Nilotinib (Tasigna®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    In line with NICE 
    Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
    Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
       
    Pazopanib (Votrient®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA215: Renal cell carcinoma (first line metastatic) - pazopanib
       
    Ponatinib (Iclusig®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA451:Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
       
    Regorafenib (Stivarga® )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • NHS E commissioned 
  • Link  NICE TA 555:Regorafenib for previously treated advanced hepatocellular carcinoma
    Link  NICE TA 488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
       
    Sorafenib (Nexavar®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
       
    Sunitinib (Sutent®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA449: Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
    Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
    Link  NICE TA178: Renal cell carcinoma
    Link  NICE TA169: Renal cell carcinoma - sunitinib
       
    Cytotoxic Drug Temsirolimus (Torisel®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA178: temsirolimus for first-line treatment of advanced and/or metastatic renal cell carcinoma
    Link  NICE TA207: Mantle cell lymphoma (relapsed) - temsirolimus (terminated appraisal)
       
    Tivozanib (Fotivda®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA512:Tivozanib for treating advanced renal cell carcinoma
       
    Vemurafenib (Zelboraf®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA176: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation-positive malignant melanoma
    Link  NICE TA269: Melanoma (BRAF V600 mutation positive, unresectable metastatic) - vemurafenib
       
    08.01.05  Taxanes
    Cytotoxic Drug Cabazitaxel (Jevtana®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
  • In line with NICE 
  • Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel (updated Aug 2016)
       
    Cytotoxic Drug Docetaxel
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE NG101: Early and locally advanced breast cancer: diagnosis and management
    Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
       
    Cytotoxic Drug Paclitaxel
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE  
  • Link  NICE NG101: Early and locally advanced breast cancer: diagnosis and management
    Link  NICE TA55: Ovarian cancer - paclitaxel (review)
       
    Cytotoxic Drug Paclitaxel - Albumin Bound Formulation (Abraxane®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
    High Cost Medicine
  • In line with NICE 
  • Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
       
    08.01.05  Topoisomerase I inhibitors
    Cytotoxic Drug Topotecan (Hycamtin®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA183: Cervical cancer (recurrent) - topotecan
    Link  NICE TA184: Lung cancer (small-cell) - topotecan
    Link  NICE TA389: Ovarian cancer (recurrent) - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine
       
    08.01.05  Trabectedin to top
    08.01.05  Trastuzumab
    Cytotoxic Drug Pertuzumab (Perjeta®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE
     
    Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
    Link  NICE TA569: Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
    Link  TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
       
    Cytotoxic Drug Trastuzumab (Herceptin®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    In line with NICE 
    Link  NICE NG101: Early and locally advanced breast cancer: diagnosis and management
    Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
    Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
    Link  NICE TA34: Breast cancer (advanced)- trastuzumab
       
    Cytotoxic Drug Trastuzumab emtansine (Kadcyla®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    In line with NICE 
    Link  NICE TA458: Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
       
    08.01.05  Tretinoin
    08.01.05  Vismodegib
    08.02  Drugs affecting the immune response
    08.02  Immunosuppressant therapy to top
    08.02.01  Antiproliferative immunosuppressants
    Azathioprine
    (tablets/suspension)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Oncology/haematology 
  • Link   ESCA: Azathioprine in conjunction with prednisolone in ILD.
    Link  ESCA Azathioprine (dermatology)
    Link  ESCA: Azathioprine in IBD
    Link  ESCA: Azathioprine in RA or PA.
    Link  UKMI Q&A: Can mothers breastfeed while taking azathioprine?
       
    Mycophenolate Mofetil
    (tablets/suspension/capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    High Cost Medicine

    Red Traffic Light  Renal Post transplant- new patients
    Amber Traffic Light  Renal Post transplant-patients initiated pre April 2013

    • For use in connective tissue diseases (Rheumatology)Click here
     
       
    Mycophenolate Sodium (Myfortic®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.02.02  Corticosteroids and other immunosuppressants
    AdoPORT® (Tacrolimus)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ciclosporin (Neoral® Sandimmun®)
    (capsules/solution)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Red Traffic Light  Post transplant- if prescribing is NOT established with GP before 1st April 2013
    Amber Traffic Light  Post transplant - if prescribing IS established with GP before 1st April 2013

     
       
    Sirolimus (Rapamune®)
    (tablets/solution)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Red Traffic Light  Post transplant- if prescribing is NOT established with GP before 1st April 2013
    Amber Traffic Light  Post transplant- if prescribing IS established with GP before 1st April 2013

     
       
    Tacrolimus
    (prolonged-release)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Prescribe by brand name only and do not switch  to minimise the risk of inadvertent switching between products, which has been associated with reports of toxicity and graft rejection (June 2012)

    • Advagraf ®: prolonged release capsule, once daily dosage

      Red Traffic Light  Post transplant- if prescribing is NOT established with GP before 1st April 2013
      Amber Traffic Light  Post transplant - if prescribing IS established with GP before 1st April 2013
     
       
    Tacrolimus
    (immediate- release)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Prescribe by brand name only to minimise the risk of inadvertent switching between products, which has been associated with reports of toxicity and graft rejection (June 2012)

    • Prograf ®: immediate- release capsule, twice daily dosage

      Red Traffic Light  Post transplant- if prescribing is NOT established with GP before 1st April 2013
      Amber Traffic Light  Post transplant - if prescribing IS established with GP before 1st April 2013
     
       
    08.02.03  Anti-lymphocyte monoclonal antibodies
    Alemtuzumab (Lemtrada®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA312: Alemtuzumab for treating relapsing‑remitting multiple sclerosis
       
    Atezolizumab (Tecentriq®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
  • In line with NICE 
  • Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
    Link  NICE TA520: Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
    Link  NICE TA 492: Atezolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
    Link  NICE TA584: Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
       
    Avelumab (Bavencio®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • Hospital only
    • In line with NICE
     
    Link  NICE TA517: Avelumab for treating metastatic Merkel cell carcinoma
       
    Blinatumomab (Blincyto®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA450: Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia
    Link  NICE TA589: Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity
       
    Dinutuximab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA 538: Dinutuximab beta for treating neuroblastoma
       
    Gemtuzumab (Mylotarg®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA545: Gemtuzumab ozogamicin for untreated acute myeloid leukaemia
       
    Inotuzumab ozogamicin (Besponsa ®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

    Hospital only- NHSE commissioned

     
    Link  NICE TA 541: Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
       
    Nivolumab (Opdivo®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    Cancer Drugs Fund
    In line with NICE
    Hospital only- NHSE Commissioned 
    Link  Nivolumab with ipilimumab for untreated advanced renal cell carcinoma [TA581]
    Link  NICE TA 558:Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease
    Link  NICE TA 490: Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
    Link  NICE TA 484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
    Link  NICE TA 483: Nivolumab for previously treated squamous non-small-cell lung cancer
    Link  NICE TA 462: Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
    Link  NICE TA 417: Nivolumab for previously treated advanced renal cell carcinoma
    Link  NICE TA 400: Nivolumab in combination with ipilimumab for treating advanced melanoma
       
    Obinutuzumab (Gazyvaro®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE
    Hospital only- NHS England commissioned 
    Link  NICE TA513: Obinutuzumab for untreated advanced follicular lymphoma
    Link  NICE TA472: Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
    Link  NICE TA343: Untreated chronic lymphocytic leukaemia- obinutuzumab in combination with chlorambucil
       
    Ocrelizumab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

     
    Link  NICE TA533: Ocrelizumab for treating relapsing–remitting multiple sclerosis
    Link  NICE TA585: Ocrelizumab for treating primary progressive multiple sclerosis
       
    Ofatumumab (Arzerra®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • NHS England is responsible commissioner for its use in untreated chronic lymphocytic leukaemia (as per NICE TA 344)
     
  • Link  NICE TA202: Chronic lymphocytic leukaemia refractory to fludaribine and alemtuzumab - ofatumumab is NOT recommended
    Link  NICE TA344: Untreated Chronic lymphocytic leukaemia- ofatumumab in combination with chlorambucil or bendamustine.
    Link  NICE TA470: Ofatumumab with chemotherapy for treating chronic lymphocytic leukaemia (terminated appraisal)
       
    Cytotoxic Drug Rituximab
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • NHSE is the responsible commissioner.In line with NICE 
  • Link  NICE TA243: Rituximab for the first-line treatment of stage III-IV follicular lymphoma
    Link  NICE TA226: Lymphoma (follicular non-Hodgkin’s) - rituximab
    Link  NICE TA193: Leukaemia (chronic lymphocytic, relapsed) - rituximab
    Link  NICE TA174: Leukaemia (chronic lymphocytic, first line) - rituximab
    Link  NICE TA 561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
    Link  NICE TA137: Lymphoma (follicular non-Hodgkin’s) - rituximab
       
    08.02.04  Other immunomodulating drugs
    Axicabtagene ciloleucel  (YESCARTA®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
    NHS England
    • In line with NICE
     
    Link  NICE TA 559: Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies
       
    Cladribine (Mavenclad®)
    (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
  • In line with NICE
  • Hospital only- NHSE commissioned 
  • Link  NICE TA 493: Cladribine tablets for treating relapsing–remitting multiple sclerosis
       
    Pomalidomide (Imnovid®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • In line with NICE TA
     
    Link  NICE TA 427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
       
    Sarilumab (Kevzara®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • In line with NICE
  • Commissioned by CCGs.  
  • Link  NICE TA 485: Sarilumab for moderate to severe rheumatoid arthritis
       
    08.02.04  Interferon Alfa to top
    Interferon Alfa
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • Hospital only
  • In line with NICE 
  • Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
       
    Peginterferon Alfa
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • Hospital only
  • In line with NICE
     
  • Link  NICE TA106: Hepatitis C - peginterferon alfa & ribavirin
    Link  NICE TA200: Hepatitis C - peginterferon alfa & ribavirin
    Link  NICE TA300: Hepatitis C (children and young people) - peginterferon alfa and ribavirin
    Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin & alfa interferon
       
    08.02.04  Interferon beta
    Interferon Beta (Avonex®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Interferon Beta (Betaferon®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Interferon beta (Extavia®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Interferon Beta (Proleukin®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Interferon Beta (Rebif®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    08.02.04  Interferon gamma
    08.02.04  Aldesleukin
    08.02.04  BCG bladder instillation
    08.02.04  Canakinumab to top
    08.02.04  Dimethyl fumarate
    Dimethyl fumarate (Tecfidera®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • For use in relapsing-remitting Multiple Sclerosis- NHSE commissioned
  • In line with NICE 
  • Link  NICE TA320: Dimethyl fumarate for treating relapsing‑remitting multiple sclerosis
       
    08.02.04  Fingolimod
    Fingolimod
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
       
    08.02.04  Glatiramer acetate
    Glatiramer Acetate (Copaxone®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • Hospital use only
     
    Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
       
    08.02.04  Histamine
    08.02.04  Lenalidomide, pomalidomide, and thalidomide to top
    Lenalidomide
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA171: Multiple myeloma - lenalidomide
    Link  NICE TA586: Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib
    Link  NICE TA587: Lenalidomide plus dexamethasone for previously untreated multiple myeloma
       
    Thalidomide capsules
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • In line with NICE 
  • Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
       
    08.02.04  Mifamurtide
    Mifamurtide
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA235: Mifamurtide for the treatment of osteosarcoma
       
    08.02.04  Natalizumab
    Natalizumab (Tysabri®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA127: Multiple sclerosis - natalizumab
       
    08.02.04  Teriflunomide
    Teriflunomide (Aubagio®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • In line with NICE 
  • Link  NICE TA303: Teriflunomide for relapsing remitting MS
       
    08.03  Sex hormones and hormone antagonists in malignant disease
    08.03.01  Oestrogens to top
    Diethylstilbestrol
    (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
    High Cost Medicine
     
       
    08.03.02  Progestogens
    Medroxyprogesterone Acetate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Megestrol Acetate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Norethisterone
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    08.03.03  Androgens
    08.03.04  Hormone antagonists
    08.03.04.01  Breast cancer
    Anastrozole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Exemestane
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Fulvestrant (Faslodex®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA503: Fulvestrant for untreated locally advanced or metastatic oestrogen-receptor positive breast cancer
    Link  NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
       
    Letrozole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Tamoxifen
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    08.03.04.02  Prostate cancer and gonadorelin analogues to top
    08.03.04.02  Gonadorelin analogues
    Degarelix
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
    High Cost Medicine
    • Commissioned by CCGs, in line with NICE
    • Transfer to Primary Care supported by an ESCA. Click here
      to access
     
    Link  NICE TA404:Degarelix for treating advanced hormone-dependent prostate cancer
       
    08.03.04.02  Anti-androgens
    Abiraterone (Zytiga®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    Cancer Drugs Fund
     
    Link  NICE TA259: Abiraterone for castration resistant prostate cancer
    Link  NICE TA387: Abiraterone for metastatic hormone-relapsed prostate cancer before chemotherapy
       
    Bicalutamide
    (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Buserelin
    (nasal spray)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Listed in Chapter 6 for other indications 
  •    
    Cyproterone Acetate
    (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Enzalutamide (Xtandi®)
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
  • Hospital only- NHSE commissioned
  • In line with NICE and available from day 91 following publication of TA.
     
  • Link  NICE TA377: Metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
       
    Flutamide
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Goserelin (Zoladex®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Goserelin (Zoladex® LA)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Leuprorelin Acetate (Prostap® 3)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Leuprorelin Acetate (Prostap® SR)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Triptorelin- Decapeptyl® SR
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • Accepted on formulary January 2017 following new drug application.
  • cost-effective alternative to current formulary options and a longer administration interval. 
  •    
    08.03.04.02  Gonadotrophin-releasing hormone antagonists
    08.03.04.03  Somatostatin analogues
    Lanreotide (Somatuline Autogel®)
    View adult BNF View SPC online View childrens BNF
    Formulary Amber Traffic Light  Palliative Care use only
    Red Traffic Light  Oncology
    Red Traffic Light  Acromegaly
     
       
    Lanreotide (Somatuline® LA)
    View adult BNF View SPC online View childrens BNF
    Formulary Amber Traffic Light Palliative Care use only
    Red Traffic Light Oncology
    Red Traffic Light Acromegaly
     
       
    Lutetium (177Lu) oxodotreotide
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    In line with NICE

    Hospital only - NHSE commissioned

     
    Link  Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours
       
    Octreotide (Sandostatin Lar®)
    View adult BNF View SPC online View childrens BNF
    Formulary Amber Traffic Light Palliative Care use only
    Red Traffic Light Oncology
    Red Traffic Light Acromegaly
     
       
    Octreotide (Sandostatin®)
    View adult BNF View SPC online View childrens BNF
    Formulary Amber Traffic Light Palliative Care use only
    Red Traffic Light Oncology
    Red Traffic Light Acromegaly
     
       
     ....
     Non Formulary Items
    Cytotoxic Drug  Aflibercept  (Zaltrap®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary

    Negative NICE TA

    Link  NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
     
    Aldesleukin  (Proleukin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Amifostine  (Ethyol®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cytotoxic Drug  Amsacrine  (Amsidine®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Axitinib  (Inlyta®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Calcium Leofolinate  (Isovorin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Canakinumab  (Ilaris®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary

    Terminated appraisal: TA302 - Canakinumab for treating systemic juvenile idiopathic arthritis 

     
    Carboplatin  (Paraplatin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Daclizumab

    Non Formulary

    NICE TA withdrawn March 2018. See MHRA update

    Link  NICE TA441: Daclizumab for treating relapsing–remitting multiple sclerosis
     
    Daclizumab  (Zenapax®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Disodium Folinate  (Sodiofolin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Disodium Levofolinate

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Envarsu XR

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Envarsus

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
     
    Ethinylestradiol

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
     
    Fampridine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Goserelin-Zoladex®

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Histrelin  (Vantas®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cytotoxic Drug  Irinotecan Hydrochloride  (Campto®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary

    Negative NICE TA

    Link  Negative NICE TA 307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
    Link  Negative NICE TA 440: Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine
     
    Oxaliplatin  (Eloxatin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Padeliporfin  (TOOKAD®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
    Link  NICE TA546: Padeliporfin for untreated localised prostate cancer
     
    Palifermin  (Kepivance®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cytotoxic Drug  Pentostatin  (Nipent®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Porfimer Sodium

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Temoporfin  (Foscan®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Toremifene  (Fareston®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cytotoxic Drug  Trabectedin  (Yondelis®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Link  NICE TA185: Soft tissue sarcoma - trabectedin
    Link  NICE TA222- ovarian cancer
     
    Tretinoin

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Red
     
    Triptorelin  (Gonapeptyl Depot®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
     
    Cytotoxic Drug  Vandetanib  (Caprelsa®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Link  NICE TA550: Vandetanib for treating medullary thyroid cancer
     
    Vindesine Sulphate  (Eldisine®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Vinflunine  (Javlor®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Link  NICE TA272: Urothelial tract carcinoma (transitional cell, advanced, metastatic) - vinflunine
     
    Cytotoxic Drug  Vismodegib  (Erivedge®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary

    Negative NICE TA

    Link  Negative NICE TA 489: Vismodegib for treating basal cell carcinoma
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Prescribing in children

    The APC notes that the informed use of unlicensed medicines or of licensed medicines for unlicensed applications (‘off-label’ use) is often necessary in paediatric practice.

    The APC advises GPs to consider specialist prescribing recommendations for Green and Amber medicines that are not subject to ESCAs or RICaDs in combination with the information provided in the BNFC which goes beyond that of marketing authorisations. The BNFC has been designed for rapid reference and the information presented has been carefully selected to aid decisions on prescribing.

      

    Green

    Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications.  

    Amber

    Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate, or initiation and maintenance of prescribing in Primary Care following recommendation from a Specialist.

    Some amber medicines require agreement with the local (internal) medicines committee prior to initiation; others may require a framework to support safe transfer and maintenance of care such as a RICaD or ESCA. The Formulary will be annotated to reflect these requirements.   

    Red

    Medicines for initiation and maintenance prescribing by Specialists only  

    Black

    Non-formulary medicines- medicines not recommended for routine primary care prescribing.  

    Grey

    Positive NICE TA and /or awaiting local clarification on place in therapy ; Please contact your Medicines Optimisation team for more information.  

    netFormulary